منابع مشابه
Relief of myocardial ischemia with nitroglycerin: what is the mechanism?
THE PHYSIOLOGIC EFFECT of nitroglycerin in patients with ischemic heart disease has been a focus of intense clinical investigation. However, some disagreement about the mechanisms by which nitroglycerin relieves myocardial ischemia still exists,' for several reasons. The action of nitroglycerin may vary, depending on the dose or route of administration. Also, parenteral nitroglycerin can be giv...
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This study evaluated the effects of transient coronary occlusion on the diameter of a nonischemic vessel or a nonischemic coronary segment proximal to the site of occlusion. Awake mongrel dogs chronically instrumented with dimension crystals, Doppler flow probes, and distal pneumatic occluders on the circumflex coronary arteries were subjected to transient 2-minute circumflex occlusions (n = 9)...
متن کاملMyocardial Ischemia
Difficulties in studying myocardial metabolism with adequate time resolution have led to contradictory conclusions regarding the mechanisms causing contractile abnormalities during the early stages of ischemia. In acutely instrumented swine, we investigated whether abnormalities in subendocardial ATP, phosphocreatine, or lactate content develop rapidly enough during the first few heart beats af...
متن کاملMyocardial Ischemia
Regional myocardial blood flow and contractile function in ischemic myocardium are well matched, and there is no evidence for an oxygen supply/demand imbalance. Thus, myocardial ischemia is lack of coronary blood flow with electric, functional, metabolic, and structural consequences for the myocardium. All therapeutic interventions must aim to improve blood flow to ischemic myocardium as much a...
متن کاملConsequences of Myocardial Ischemia
Metabolic Consequences During ischemia, several metabolic changes occur. Adenosine tr iphosphate (ATP) is degraded to adenosine, which, diffusing out of cardiomyocytes, causes arteriolar di lation and anginal pain. Free fatty acids and acyl-carnit ine accumulate and protein synthesis and turnover are impaired in myocardial cells. Furthermore, myocardial ischemia/reperfusion produces free radica...
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ژورنال
عنوان ژورنال: Journal of the Japanese Coronary Association
سال: 2018
ISSN: 1341-7703,2187-1949
DOI: 10.7793/jcoron.24.014